Endocrine Abstracts

Objectives: It is well known that compounds of follicular fluid, which is rich in carbohydrates, are able to regulate the expression of angiogenesis-related genes in endothelial cells. Nuclear factor κ B (NF-κB) transcription factors are important candidates in modulating the expression of these genes. The aim of our research is to determine if NF-κB factors are maybe involved in the regulation of endothelial angiogenesis-related genes and thus in ovarian angiog...

A 40-year-old woman, who had developed oligomenorrhoea after discontinuing the contraceptive pill at age 30, presented with a 6-month history of intermittent vomiting associated with abdominal discomfort and distension. Ultrasound, followed by laparotomy, revealed multiple bilateral ovarian luteal cysts consistent with hyperoestrogenism and ovarian-hyperfunctioning.Only 9 months post-operatively her bilateral theca ovarian cysts had recurred. Over 4 mont...

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors activated by fatty acids and derivatives. While PPARalpha mediates the hypolipidemic action of fibrates, PPARgamma is the receptor for the antidiabetic glitazones. PPARalpha is highly expressed in tissues such as liver, muscle, kidney and heart, where it stimulates the b-oxidative degradation of fatty acids. PPARgamma is predominantly expressed in adipose tissues, where it promotes adipocyte differentiat...

Introduction: Chronic hepatitis and NAFLD represent a global public health problem since they are two common cause of chronic liver disease. Hepatic steatosis (HS) is becoming highly prevalent worldwide and its association with hepatitis B, although controversial previously, is increasingly encountered and thought to be related to host factors.Aim and methods: The aim of this retrospective study is to determine the prevalence of HS in chronic hepatitis B...

Introduction: Programmed death-1 (PD-1) is one of the most important inhibitory co-receptors. Studies show that the PD-1/PD-L1 pathway regulates the induction and maintenance of peripheral tolerance and protects tissues from autoimmune attack in physiological conditions. Several studies have shown association of PD-1/PD-L1 pathway with several autoimmune diseases although, to date, no such studies have been performed for Graves’ disease (GD).Aims: T...

Objective: Orexin-A and orexin-B and their G-protein coupled receptors (orexin receptor-1 & -2: OX1R, OX2R) have divergent effects on physiological behaviour, cardiovascular regulation, glucocorticoid and insulin release. Furthermore, orexins have been shown to affect both brown adipose tissue energy expenditure and thermogenesis through stimulation of sympathetic nerve activity. Despite in vivo studies demonstrating a role for orexins acting centrally on adipose ti...

Objective: Orexin-A and orexin-B and their G-protein coupled receptors (orexin receptor-1 & -2: OX1R, OX2R) have divergent effects on physiological behaviour, cardiovascular regulation, glucocorticoid and insulin release. Furthermore, orexins have been shown to affect both brown adipose tissue energy expenditure and thermogenesis through stimulation of sympathetic nerve activity. Despite in vivo studies demonstrating a role for orexins acting centrally on adipose ti...

Background: Autoimmune thyroid disorders (AITD) similar in pathomorphology picture results in hyper- or hypothyreosis. The differences between Graves’ disease (GD) and Hashimoto thyroiditis (HT) suggested that changes in the subsets of T-cells may have an influence on the course of this reaction.Methods: The study involved 90 children: 30 with GD, 30 with HT and the control group – 30 children. After thyroidectomy, standard histological examina...

Acromegaly is a rare endocrine disorder mostly caused by a growth hormone (GH)-secreting pituitary adenoma. The aim of treatment is to normalize GH/IGF1 levels to limit disease burden. Growth hormone hypersecretion is associated with an increased cancer risk; cases of Acromegaly complicated by lymphoma have been reported. We share a clinical case characterized by suboptimal treatment, potentially leading to advancing orbital lymphoma. This 49-year-old man was diagnosed with Ac...

Introduction: Type B insulin resistance syndrome is an autoimmune disorder characterized by the production of autoantibodies against the insulin receptor. It leads to glucose metabolism disorders, extreme insulin resistance, hyperandrogenism and is associated with other features of autoimmunity.Case report: A 27-year-old man, with a 2-years history of psoriasis, was admitted to our Department because of loss of weight (20 kg in 1 year) and fatigue. He al...